Polygonum Cuspidatum Extract With Resveratrol/Polydatin/Emodin

Specifications

Fallopia japonica Extract

Product Name:	Polygonum cuspidatum Extract
Botanical name:	Fallopia japonica
Active Ingredient:	Resveratrol	Polydatin	Emodin
CAS No.:	501-36-0	27208-80-6	518-82-1
Specification:	20%50%80%98%	20%50%80%98%	20%50%80%98%
Test :	HPLC	HPLC	HPLC
Appearance:	white Powder	white Powder	Yellow Powder
Formula:	C14H12O3	C21H24O8	C15H10O5
Structural Formula:
Mol. mass:	228.2433 g/mol	404.4105 g/mol	270.24 g/mol
Density	1.359g/cm3	1.433g/cm3	/
Vapour pressure	1.11E-08mmHg at 25°C	1.34E-20mmHg at 25°C	/
Melting point:	/	223-226°C (dec.) °C	253-257°C
Boiling point:	449.1°C at 760 mmHg	700.5°C at 760 mmHg	/
flash point	222.3°C	377.5°C	/
Main Function:	Improves circulatory functions	anti-inflammation	anti-inflammation
Application:	Dietary Supplement	Medicine	Medicine
Dangerous mark	Xi:Irritant	S22/S24/25	Xi:Irritant

Literature Description

Polygonum Cuspidatum flowers are valued by some beekeepers as an important source of nectar for honeybees, at a time of year when little else is flowering.  Polygonum Cuspidatum yields a monofloral honey, usually called bamboo honey by northeastern U.S. beekeepers, like a mild-flavored version of buckwheat honey (a related plant also in the Polygonaceae).

The young stems are edible as a spring vegetable, with a flavor similar to extremely sour rhubarb.

In some locations, semi-cultivating  Polygonum Cuspidatum for food has been used as a means of controlling knotweed populations that invade sensitive wetland areas and drive out the native vegetation.

 Some caution should be exercised when consuming this plant because it, similar to rhubarb, contains oxalic acid, which may aggravate conditions such as rheumatism, arthritis, gout, kidney stones or hyperacidity.

Both Polygonum Cuspidatum and giant knotweed are important concentrated sources of resveratrol and its glucoside piceid, replacing grape byproducts.

Many large supplement sources of resveratrol now use Japanese knotweed and use its scientific name in the supplement labels.

The plant is useful because of its year-round growth and robustness in different climates.

Polygonum Cuspidatum is a concentrated source of emodin, used as a nutritional supplement to regulate bowel motility.

The roots of Japanese knotweed are used in traditional Chinese and Japanese herbal medicines as a natural laxative.

The active principle responsible for the laxative effect is emodin, present in its natural form as a complex of its analogs.

Emodin has a mild laxative effect in doses of 20 to 50 mg per day.

Resveratrol

(3,5,4'-trihydroxy-trans-stilbene) is a stilbenoid, a type of natural phenol, and a phytoalexin produced naturally by several plants when under attack by pathogens such as bacteria or fungi. Resveratrol is found in the skin of red grapes and in other fruits. However, red wine contains very little of it, on the order of 0.1-14.3 mg/l. Resveratrol has also been produced by chemical synthesis and by biotechnological synthesis (metabolic engineered microorganisms) and is sold as a nutritional supplement derived primarily from Japanese knotweed.

Cardioprotective effects

Moderate drinking of red wine has long been known to reduce the risk of heart disease.

This is best known as “the French paradox”.

Studies suggest resveratrol in red wine may play an important role in this phenomenon.

Anti-diabetic effects

Studies have shown resveratrol possesses hypoglycemic and hypolipidemic effects in both streptozotocin (STZ)-induced diabetes rats and STZ-nicotinamide-induced diabetes rats. Resveratrol ameliorates common diabetes symptoms, such as polyphagia, polydipsia, and body weight loss. Other diabetic animal model studies by different researchers have also demonstrated the antidiabetic effects of resveratrol.

Neuroprotective effects

In November 2008, researchers at the Weill Medical College of Cornell University reported dietary supplementation with resveratrol significantly reduced plaque formation in animal brains, a component of Alzheimer's disease and other neurodegenerative diseases. In mice, oral resveratrol produced large reductions in brain plaque in the hypothalamus (−90%), striatum (−89%), and medial cortex (−48%) sections of the brain. In humans, oral doses of resveratrol thoretically may reduce beta amyloid plaque associated with aging changes in the brain. Researchers theorize that one mechanism for plaque eradication is the ability of resveratrol to chelate (bind) copper. The neuroprotective effects have been confirmed in several animal model studies.

Anti-inflammatory effects 

The anti-inflammatory effects of resveratrol have been demonstrated in several animal model studies. In a rat model of carrageenan-induced paw edema, resveratrol inhibited both acute and chronic phases of the inflammatory process.

Similarly, preincubation with resveratrol decreased arachidonic acid release and COX-2 induction in mouse peritoneal macrophages stimulated with tumor promoter PMA, ROI, or lipopolysaccharides (LPS). In an experimental rabbit inflammatory arthritis model, resveratrol showed promise as a potential therapy for arthritis. When administered to rabbits with induced inflammatory arthritis, resveratrol protected cartilage against the progression of inflammatory arthritis.

Antiviral effects 

Studies show resveratrol inhibits herpes simplex virus (HSV) types 1 and 2 replication by inhibition of an early step in the virus replication cycle. In vivo studies in mice found resveratrol inhibits or reduces HSV replication in the vagina and limits extravaginal disease. The skin of resveratrol-treated animals showed no apparent dermal toxicity, such as erythema, scaling, crusting, lichenification, or excoriation.  Studies also show resveratrol inhibits varicella-zoster virus, certain influenza viruses, respiratory viruses, and human cytomegalovirus. Furthermore, resveratrol synergistically enhances the anti-HIV-1 activity of several anti-HIV drugs.

Emodin

Emodin is being studied as a potential agent that could reduce the impact of type 2 diabetes. It is a potent selective inhibitor of the enzyme 11β-HSD1. In studies in obese mice, emodin limits the effect of glucocorticoids and may therefore ameliorate diabetes and insulin resistance.

Pharmacological studies have demonstrated that emodin when isolated from rhubarb exhibits anti-cancer effects on several human cancers, including human pancreatic cancer. Emodin in rhubarb extracts may also have neuroprotective properties against glutamate toxicity.

Our advantages:

1. Our factory was conducted Onsite assessment by TUV Rheinland from Germany. And we have passed the ISO9001, Chinese Health Food GMP.

2. We inspect the manufacture process strictly and the quality can be controlled;

3. We supply high quality products, reasonable price, prompt delivery

4. Or best quality extract with natural and pure. No additives, organically grown